Endocrine system · Human body

ENDOCRINE SYSTEM SIMULATION

Hormones travel by blood, far slower than nerve signals, but in exchange they reach every cell carrying the right receptor. The hypothalamus releases TRH, the pituitary TSH, the thyroid T4, and T4 then turns back to suppress both glands above it; that negative-feedback loop keeps oscillating rather than sitting still. Hyperthyroidism sends T4 surging while TSH is crushed to the floor; hypothyroidism inverts the pattern, with high TSH and stubbornly low T4.

▸ Placing the glands: hypothalamus · pituitary · thyroid · adrenal · pancreas · gonads…

▸ Linking the hypothalamic–pituitary–target axis

▸ Pumping hormones into the bloodstream

▸ Calibrating the thyroid-axis negative-feedback loop

▸ Ready — Online. ✅

Hormone levels

🧪 Hypothalamic–pituitary–thyroid axis

TSH (pituitary)—

T4 (thyroid)—

Cortisol (adrenal)—

Glucose (blood)—

Heart rate—

Selected gland—

Note

A hormone is a chemical messenger carried by the BLOOD to target organs. Negative feedback keeps things stable: high T4 → loops back to "turn down" the hypothalamus & pituitary → TSH falls → the thyroid secretes less.

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Pick a "Scenario" (hyper/hypothyroidism · stress · diabetes · negative feedback) · click each gland on the body or in the list for details

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Hormones over time (watch the feedback oscillate) TSHT4Cortisol